Electronic Detection Platform

The detection and analysis is performed electronically without expensive and delicate optical components. Ohmx biochips consist of an array of electronically active gold electrodes, used to simultaneously detect different analytes within a single sample (see figure below). Ohmx’s detection technology relies on the production of an electrochemically active product, which in turn generates an electrocatalytic signal on the electrode. This signal is proportional to the concentration of  target analytes and other clinical indicators. 

Each electrode of the sensor’s microarray is individually spotted and uniquely modified to include  a mixed monolayer of  the sensing element that has the following key features:       

- A molecular wire that anchors it to the electrode and is used to shuttle electrons       

- A redox active metal complex, whose signal is measured after sample addition       

- A specific probe moiety that dictates the assay construct. This probe may consist of a self--immolative  group that works in conjunction with standard immunoassay approaches or a group with scissile bonds  recognizable specifically by different target proteases.

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